British Air Force Typhoon FGR4s have conducted a mission with French warplanes in a joint strike targeting an hidden munitions depot in Syrian territory used by the IS group, according to the UK's MoD.
The location, located using reconnaissance, was believed to be containing munitions and bombs, the announcement noted, and was positioned in mountainous terrain just to the north of the historic site of Palmyra in Syria's central region.
"Our fighter planes employed precision-guided Paveway IV munitions to strike a several approach shafts providing entry to the facility... initial indications suggest the objective was successfully hit," the MoD said.
There was no indication of any harm to civilians in the operation conducted Saturday night and all the aircraft made a safe return, the MoD added.
The Typhoon fighters were backed up by a Voyager aerial refuelling aircraft.
Daesh - referred to as Daesh - enforced militant control over significant areas in both Syria and Iraq before its territorial defeat in 2019.
"This operation shows our UK leadership, and determination to operate in unison with our partners, to stamp out any revival of IS and their dangerous and violent ideologies in the Middle East," the British Defence Secretary the minister remarked.
RAF aircraft have carried out patrols over Syria to "forestall any efforts to regroup" of the group following its routing at the battle of Baghuz in 2019, the authorities noted.
"I must thank all the members of our armed forces involved in this strike for their professionalism and their courage," Healey added. "Including them were thousands of British personnel deployed over the festive period. This operation, to remove dangerous terrorists who threaten our way of life, shows how British military are ready to step up, continuously, ensuring Britain's security at home and strong abroad."
Last December, the US military carried out what it termed a "major assault" targeting Islamic State objectives in Syria, after an attack claimed the lives of two US servicemembers and a local interpreter in the Palmyra area.
The United Nations reports Daesh still has an estimated 5,000 to 7,000 combatants in Iraq and Syria.